I am Fatigued, Won’t Exercise Make Me More Tired and Fatigued? Dr. Rebecca Manno explains how exercise boosts energy levels and improves sleep. The best thing to do is to get started on an exercise routine so that fatigue decreases with time. In This VideoRebecca Manno, MD, MHSDr. Manno is an Assistant Professor of Medicine in the Division of Rheumatology. The focus of her research is the effect of inflammatory arthritis and vasculitis on muscle, strength, and function; particularly in older patients.